Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment
Authors:
- Bernard N. FieldsBFBernard N. Fields
- Mark I. GreeneMGMark I. Greene
- 1 November 1982
- journal article
- Published by Springer Nature in Nature
- Vol. 300 (5887) , 19-23
Abstract
The pathogenesis of infection of mice by the mammalian reoviruses involves several discrete steps. Each of the three viral outer capsid proteins has a highly distinct and specialized role: one protein (sigma 1) binds to cell surface receptors; a second protein (mu 1C) determines the capacity for viral growth at mucosal surfaces; and the third protein (sigma 3) is responsible for inhibiting cell macromolecular synthesis. A detailed picture of the molecular basis of reovirus virulence and attention is now emerging.Keywords
This publication has 42 references indexed in Scilit:
- Molecular basis of reovirus virulenceArchives of Virology, 1982
- Attenuated reovirus type 3 strains generated by selection of haemagglutinin antigenic variantsNature, 1982
- Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies.Journal of Experimental Medicine, 1982
- Role of the S4 gene in the establishment of persistent reovirus infection in L cellsCell, 1982
- Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells.Journal of Experimental Medicine, 1982
- Idiotypy of clonal responses to influenza virus hemagglutinin.Journal of Experimental Medicine, 1981
- Absolute Linkage of Virulence and Central Nervous System Cell Tropism of Reoviruses to Viral HemagglutininThe Journal of Infectious Diseases, 1980
- Molecular basis of infectivity and pathogenicity of myxovirusArchives of Virology, 1979
- Mechanisms of viral persistenceCell, 1978
- Temperature-Sensitive Mutants of ReovirusIntervirology, 1974