HYPERHOMOCYSTEINEMIA IN CYCLOSPORINE-TREATED RENAL TRANSPLANT RECIPIENTS1

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Abstract
Moderate hyperhomocysteinemia, an independent cardiovascular risk factor, has been reported in renal transplant recipients. In the present study, plasma concentrations of total homocysteine were significantly increased in 120 renal transplant recipients as compared with 60 healthy controls (19.0±6.9 vs. 11.6±2.8 μmol/L,PPr = -0.52, P12concentrations. Renal transplant recipients on cyclosporine had significantly higher plasma homocysteine concentrations than those not on cyclosporine (19.5±7.6 vs. 16.2±4.8 μmol/L, PP. Plasma homocysteine concentrations were significantly increased in 24 patients with a history of atherosclerotic complications as compared with the remaining 96 renal transplant recipients (20.8±4.4 vs. 18.5±7.3 μmol/L, P.

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