Exploring the Diet-Gut Microbiota-Epigenetics Crosstalk Relevant to Neonatal Diabetes
Open Access
Abstract
Neonatal diabetes (NDM) is a rare monogenic disorder that presents as hyperglycemia during the first six months of life. The link between early-life gut microbiota dysbiosis and susceptibility to NDM remains uncertain. Experimental studies have demonstrated that gestational diabetes mellitus (GDM) could develop into meconium/gut microbiota dysbiosis in newborns, and thus, it is thought to be a mediator in the pathogenesis of NDM. Epigenetic modifications have been considered as potential mechanisms by which the gut microbiota and susceptibility genes interact with the neonatal immune system. Several epigenome-wide association studies have revealed that GDM is associated with neonatal cord blood and/or placental DNA methylation alterations. However, the mechanisms linking diet in GDM with gut microbiota alterations, which may in turn induce the expression of genes linked to NDM, are yet to be unraveled. Therefore, the focus of this review is to highlight the impacts of diet, gut microbiota, and epigenetic crosstalk on altered gene expression in NDM.Keywords
This publication has 130 references indexed in Scilit:
- Diversified Microbiota of Meconium Is Affected by Maternal Diabetes StatusPLOS ONE, 2013
- Peroxisome Proliferator-activated Receptor γ (PPARγ) and Its Target Genes Are Downstream Effectors of FoxO1 Protein in Islet β-CellsJournal of Biological Chemistry, 2013
- The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesisBest Practice & Research Clinical Endocrinology & Metabolism, 2012
- Neonatal Diabetes: An Expanding List of Genes Allows for Improved Diagnosis and TreatmentCurrent Diabetes Reports, 2011
- Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell DeathDiabetes, 2011
- Neonatal diabetes mellitus: A model for personalized medicineTrends in Endocrinology & Metabolism, 2010
- Hydrogen peroxide stimulates nuclear import of the POU homeodomain protein Oct-1 and its repressive effect on the expression of Cdx-2BMC Cell Biology, 2010
- Gene expression of PPARγ and PGC-1α in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical trainingEuropean Journal of Endocrinology, 2010
- Enterococcus faecalis from newborn babies regulate endogenous PPARγ activity and IL-10 levels in colonic epithelial cellsProceedings of the National Academy of Sciences, 2008
- The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndromeJournal of Medical Genetics, 2003