Exercise capacity, energy metabolism, and beta-adrenoceptor blockade

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Abstract
The effects of beta1 and beta1/2 blockade on exercise capacity were studied in 9 healthy normotensive subjects. Progressive maximal bicycle ergometer tests, followed by an endurance test at 80% of maximal work load, were performed during randomized, double-blind 3 day treatment periods with placebo, atenolol (beta1) and oxprenolol (beta1/2). The reduction of maximal work capacity (ca. 10%) was similar with atenolol and oxprenolol, despite a more pronounced maximal heart rate reduction with atenolol (from 175±2 to 132±3 beats · min−1) than with oxprenolol (to 138±2 beats · min−1). Exercise time during the endurance test was reduced from 36±4 min with placebo to 27±3 min with atenolol (ppp1-selective beta blockade. This reduction may be related to the effects of beta1 blockade on energy metabolism, with possibly an additional effect of beta2 blockade.

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