Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders
- 18 November 2021
- journal article
- research article
- Published by Elsevier in European Journal of Medicinal Chemistry
- Vol. 229, 114002
Abstract
No abstract availableKeywords
This publication has 52 references indexed in Scilit:
- Therapeutics targeting the inflammasome after central nervous system injuryTranslational Research, 2016
- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategiesExperimental & Molecular Medicine, 2015
- Innate immunity in Alzheimer's diseaseNature Immunology, 2015
- The Inflammasomes and Autoinflammatory SyndromesAnnual Review of Pathology: Mechanisms of Disease, 2015
- Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectivesJournal of Inflammation Research, 2015
- Inflammasomes and Metabolic Disorders: Old Genes in Modern DiseasesMolecular Cell, 2014
- Chemistry and Biology Of Multicomponent ReactionsChemical Reviews, 2012
- Efficient Multicomponent Reaction Synthesis of the Schistosomiasis Drug PraziquantelChemistry – A European Journal, 2010
- Caspases as therapeutic targetsJournal of Cellular and Molecular Medicine, 2008
- A common allosteric site and mechanism in caspasesProceedings of the National Academy of Sciences, 2006