Prognostic Implications of Pulmonary Hypertension in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation

Authors:
  • ALAdrien Luçon
    Adrien Luçon
  • EOEmmanuel Oger
    Emmanuel Oger
  • MBMarc Bedossa
    Marc Bedossa
  • DBDominique Boulmier
    Dominique Boulmier
  • JVJean Philippe Verhoye
    Jean Philippe Verhoye
  • HEHélène Eltchaninoff
    Hélène Eltchaninoff
  • ALAlain Leguerrier
    Alain Leguerrier
  • MLMarc Laskar
    Marc Laskar
  • PLPascal Leprince
    Pascal Leprince
  • MGMartine Gilard
    Martine Gilard
  • HBHervé Le Breton
    Hervé Le Breton
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Abstract
Background—: Pulmonary hypertension (PH) is associated with poor prognosis in patients with severe aortic stenosis. The aim of this multicenter study was to describe clinical outcome after transcatheter aortic valve implantation. Methods and Results—: The FRANCE 2 Registry included all patients undergoing transcatheter aortic valve implantation in France in 2010 and 2011. Patients were divided into 3 groups depending on systolic pulmonary artery pressure (sPAP) estimated in transthoracic echocardiography: group I, sPAP P =0.032). Mild-to-moderate and severe PH were identified as an independent factor of all-cause mortality. The major adverse cardiovascular event rates did not differ according to sPAP. New York Health Association functional class improved significantly in all groups. Conclusions—: PH (sPAP ≥40 mm Hg) in patients with aortic stenosis undergoing transcatheter aortic valve implantation was associated with increased 1-year mortality especially when severe (sPAP ≥60 mm Hg) but not with increased 30-day mortality, and functional status was significantly improved regardless of PAP level.

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