Antimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanes
Open Access
- 1 January 2003
- journal article
- Published by National Library of Serbia in Journal of the Serbian Chemical Society
- Vol. 68 (4-5) , 291-302
Abstract
Mixed tetraoxanes of the 4"-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl- spirocholate series have been prepared and evaluated as possible antimalarials, antiproliferatives and antimycobacterials. The activity of the (4"R or S)-phenyl series against P. falciparum D6 and W2 strains was found to be at the level of artemisinin with two compounds, the acid 4 and the amide 6, exhibiting encouraging anti-TB activity as well. Very promising in vitro results of the said tetraoxanes were obtained against solid tumours and, in some instances, the activity against a selected number of cell lines was higher than that of the antitumor drug Paclitaxel.Keywords
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