Enhanced systemic matrix metalloproteinase response inHelicobacter pylorigastritis

Authors:
  • AOAino M. Oksanen
    Aino M. Oksanen
  • LVLea I. Veijola
    Lea I. Veijola
  • PSPentti I. Sipponen
    Pentti I. Sipponen
  • TTTaina I. Tervahartiala
    Taina I. Tervahartiala
  • TSTimo A. Sorsa
    Timo A. Sorsa
  • ALAnneli Lauhio
    Anneli Lauhio
Publisher website
Google Scholar
Abstract
Helicobacter pylori causes chronic gastritis, peptic ulcer disease, and is the most important risk factor for non-cardia gastric cancer, and has been shown to upregulate matrix metalloproteinases (MMPs) in infected gastric mucosa. MMPs are proteolytic enzymes regulated by tissue inhibitors of metalloproteinases (TIMPs). We set up this study to find out whether H. pylori gastritis induces systemic MMP response. Serum samples were collected from patients undergoing gastroscopy; 26 patients had H. pylori gastritis and 18 were H. pylori-negative controls with normal gastric mucosa. Serum MMP levels were analysed by enzyme-linked immunosorbent assay. Significantly elevated serum levels of collagenase-2 (MMP-8), gelatinase B (MMP-9), neutrophil elastase (NE), and myeloperoxidase (MPO), and reduced serum levels of gelatinase A (MMP-2) and TIMP-1 were demonstrated in patients with H. pylori gastritis as compared to H. pylori-negative controls. No significant differences were shown in serum matrilysin-1 (MMP-7) levels. For the first time, we show enhanced MMP-8 response in H. pylori infection together with other neutrophil degranulation products (MMP-9, MPO, NE). Elevated circulating neutrophil degranulation product levels in serum of H. pylori-positive patients reflect accelerated proteolysis and oxidative stress, and may contribute to extraintestinal sequelae, such as cardiovascular diseases.

This publication has 39 references indexed in Scilit: