Human Interferon-γ Protects Rhesus Monkeys Against Sporozoite-Induced Plasmodium cynomolgi Malaria Infection

Authors:
  • RMRadha K. Maheshwari
    Radha K. Maheshwari
  • GDG.P. Dutta
    G.P. Dutta
  • RFRobert M. Friedman
    Robert M. Friedman
  • MDM.M. Dhar
    M.M. Dhar
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Abstract
Earlier we reported that prophylactic treatment with recombinant human interferon gamma (rHuIFN-γ) for a prolonged duration completely suppressed experimental infection with Plasmodium cynomolgi B sporozoites in rhesus monkeys. We now show that reducing the rHuIFN-γ treatment to three administrations given close to the time (on days -1, 0, and +1) of infection was sufficient for complete protection. Animals initially protected by rHuIFN-γ treatment are susceptible to reinfection. Studies are in progress to understand the precise mechanism of protection afforded by HuIFN-γ against sporozoite-induced malaria infection.

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