The importance of oxidative stress in pathogenesis of type 1 diabetes: Determination of catalase activity in lymphocytes of diabetic patients

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Abstract
Introduction. Type 1 diabetes is a protoype of disease with an intesive oxidative stress. The oxidative stress means disturbing dynamic balance between prooxidants and antioxidants, either due to the increased production of the oxygen free radicals or the decreased antioxidant activity. The antioxidative enzyme catalase diminishes free radical hydrogen-peroxyde, which can be very toxic to pancreatic cells. Material and methods. Our study included 40 children with type 1 diabetes. We analyzed the activity of enzyme catalase in lymphocytes in different phases of disease: at the beginning of diabetes, in remission period and in the later chronic course. Results There is a significant increase in the catalase activity during all phases of disease (p

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