Reference viruses for seasonal and pandemic influenza vaccine preparation
Authors:
Open Access
- 19 January 2007
- journal article
- review article
- Published by Wiley in Influenza and Other Respiratory Viruses
- Vol. 1 (1) , 5-9
Abstract
The production of seasonal and pandemic influenza vaccines depends on the timely availability of suitable reference viruses. Seasonal vaccines are traditionally produced from high‐growth reassortant viruses, which have been derived empirically using well‐established techniques. However, it is not possible to use such approaches in deriving vaccine reference viruses from highly pathogenic H5N1 viruses and alternative techniques such as reverse genetics must be employed.Keywords
This publication has 14 references indexed in Scilit:
- Influenza pandemic vaccines: how to ensure a low-cost, low-dose optionNature Reviews Microbiology, 2006
- Immunization with Reverse‐Genetics–Produced H5N1 Influenza Vaccine Protects Ferrets against Homologous and Heterologous ChallengeThe Journal of Infectious Diseases, 2006
- Outbreak news. Avian influenza, Nigeria.2006
- Generation of influenza vaccine viruses on Vero cells by reverse genetics: an H5N1 candidate vaccine strain produced under a quality systemVaccine, 2005
- Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccinesThe Lancet, 2004
- Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenzaThe Lancet, 2001
- A DNA transfection system for generation of influenza A virus from eight plasmidsProceedings of the National Academy of Sciences, 2000
- RNAs of influenza virus recombinants derived from parents of known virulence for manArchives of Virology, 1977
- TRIALS IN MAN WITH LIVE RECOMBINANTS MADE FROM A/PR/8/34 (H0 N1) AND WILD H3 N2 INFLUENZA VIRUSESThe Lancet, 1975
- A VIRUS OBTAINED FROM INFLUENZA PATIENTSThe Lancet, 1933