Large-scale analysis of microRNA evolution
Open Access
- 1 January 2012
- journal article
- Published by Springer Nature in BMC Genomics
- Vol. 13 (1) , 218
Abstract
In animals, microRNAs (miRNA) are important genetic regulators. Animal miRNAs appear to have expanded in conjunction with an escalation in complexity during early bilaterian evolution. Their small size and high-degree of similarity makes them challenging for phylogenetic approaches. Furthermore, genomic locations encoding miRNAs are not clearly defined in many species. A number of studies have looked at the evolution of individual miRNA families. However, we currently lack resources for large-scale analysis of miRNA evolution.Keywords
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