Effect of Out-of-Hospital Sodium Nitrite on Survival to Hospital Admission After Cardiac Arrest

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Abstract
Out-of-hospital cardiac arrest is a common cause of premature morbidity and mortality and hence a major public health challenge.1 Existing treatments for out-of-hospital cardiac arrest combine cardiopulmonary resuscitation (CPR) and early defibrillation by bystanders or first responders with advanced cardiac life support by emergency medical services (EMS) personnel. The advanced life support treatments include CPR, defibrillation, intravenous drugs, and postresuscitation care.2-4 Neurological injury is the major cause of morbidity and mortality in these patients; most resuscitated patients never regain consciousness.5-8 Despite advances in resuscitation, more than 80% of those in whom circulation was restored after out-of-hospital cardiac arrest died before hospital discharge in studies with data collected between 2005 and 2015.9,10

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