Serotonin uptake inhibitors: Uses in clinical therapy and in laboratory research

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Abstract
Shortly after serotonin was discovered to be present in the brain in 1953, it was suspected to be a neurotransmitter there. Just over 40 years later, much has been learned about brain serotonin neurons and their physiological roles. One contributor to this advance in knowledge has been a group of compounds that selectively inhibit serotonin uptake. The study of these compounds in laboratory animals has not only given insight into the operation of serotonin neurons themselves and how the synthesis and release of serotonin is controlled, but also has helped in the understanding of physiological roles of serotonin neurons. Moreover, these serotonin uptake inhibitors have been therapeutically useful in treating mental depression, bulimia and obsessive-compulsive disorder in humans, and there is some indication they may have therapeutic effects in a variety of other diseases. The continued study of these compounds will further increase our knowledge about the role of serotonin in disease and may lead to ways of enhancing their therapeutic effects.

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