Combination chemotherapy followed by autologous stem cell transplant for enteropathy‐associated T cell lymphoma
- 20 November 2006
- journal article
- clinical trial
- Published by Wiley in British Journal of Haematology
- Vol. 136 (1) , 111-113
Abstract
Summary: Enteropathy‐associated T cell lymphoma (EATL) is a rare entity associated with coeliac disease, with a poor prognosis due to perforation and gastro‐intestinal bleeding during treatment, and a high relapse risk. Six patients were treated with two cycles of IVE (ifosphamide, etoposide, epirubicin), followed by two cycles of high‐dose methotrexate (3 g/m2) with folinic acid rescue and a BEAM (carmustine, etoposide, cytarabine, melphalan) autograft. Enteral feeding was given throughout treatment. Four patients remain alive in complete remission at 1·83–4·32 years; two have relapsed. Given the historically poor outcome in these patients, this regimen appears very promising in the treatment of EATL.Keywords
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