Three classes and four (sub)classes of rat immunoglobulins: IgM, IgA, Ige and IgG1, IgG2a, IgG2b, IgG2c
Authors:
- 1 January 1974
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 4 (1) , 44-48
Abstract
Class or subsclass‐specific differences have been investigated in the monoclonal immunoglobulins produced by 184 secreting immunocytomas raised in the LOU/Wsl inbred strain of rats. Seven classes or subclasses of rat immunoglobulins were detected and the names IgM, IgA, IgE, IgG1, IgG2a, IgG2b and IgG2c proposed for them. The sedimentation coefficients of rat IgG1, IgG2a and IgG2c were found to be respectively, 6.7, 6.4 and 6.7 S. Rat IgG1, IgG2a and IgG2c were found to cross‐react with antisera to human γ‐chains.Keywords
This publication has 21 references indexed in Scilit:
- Lambda light chains in rat immunoglobulinsImmunochemistry, 1973
- Transplantable Immunoglobulin‐Secreting Tumours in RatsEuropean Journal of Biochemistry, 1972
- A NEW MOUSE IMMUNOGLOBULIN: IGG3Journal of Experimental Medicine, 1971
- Serum and secretory immunoglobulins of the ratImmunochemistry, 1970
- Further studies on singel radial immunodiffusion—II The reversed system: Diffusion of antibodies in antigen-containing gelsImmunochemistry, 1969
- The Cross-linking of Proteins with Glutaraldehyde and its use for the preparation of immunoadsorbentsImmunochemistry, 1969
- Characterization of Rat IgA and Its Non-Identity with the Anaphylactic AntibodyInternational Archives of Allergy and Immunology, 1966
- Immunochemical quantitation of antigens by single radial immunodiffusionImmunochemistry, 1965
- Heterogeneity of Rat ImmunoglobulinsInternational Archives of Allergy and Immunology, 1965
- Immunoglobulin Abnormalities of the Thymectomized RatNature, 1963