Differences in the characteristics of opioid receptor binding in the rat and marmoset
Authors:
- 1 October 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 40 (10) , 736-739
Abstract
The density of μ and δ opioid binding sites in homo-genates of rat and marmoset brain was determined using radio-labelled peptides with high receptor selectivity. In addition the affinity of μ and δ receptor binding of five drugs of the fentanyl series was measured. The ratio of μ:δ sites was similar within each species but the total receptor binding capacity in the rat was double that of the marmoset. The binding affinities for the δ site were dissimilar between the species and supports the hypothesis that the structure of this receptor shows phylogenetic differences. In contrast, μ site binding affinity was identical in rat and marmoset.Keywords
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