Antitumor Activity of Hypsizigus marmoreus. I. Antitumor Activity of Extracts and Polysaccharides.

Authors:
  • HSHideharu Saitoh
    Hideharu Saitoh
  • WFWeijian Feng
    Weijian Feng
  • HZHuiling Zhang
    Huiling Zhang
  • LLLangfang Li
    Langfang Li
  • TMTsunetomo Matsuzawa
    Tsunetomo Matsuzawa
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Abstract
Antitumor activity of Hypsizigus marmoreus, one of the most popular Japanese edible mushrooms, was investigated. The aqueous and methanol extracts were tested against allogeneic tumor, solid sarcoma 180 and syngeneic tumor, Meth A fibrosarcoma. The aqueous extract was highly active in inhibiting growth of solid sarcoma 180, but not as much for Meth A fibrosarcoma. Fractionation of antitumor substances of the aqueous extract isolated four polysaccharides. Chemical analysis revealed one of them to be beta-(1-3)-glucan with a remarkable inhibitory effect against tumor-growth of sarcoma 180.