Case Series of Different Onset of Skin Metastasis According to the Breast Cancer Subtypes
Authors:
Open Access
- 1 April 2014
- journal article
- Published by Korean Cancer Association in Cancer Research and Treatment
- Vol. 46 (2) , 194-199
Abstract
We report on five cases of skin metastasis according to the breast cancer (BC) subtype. Two cases of HER2 positive BC showed only skin metastasis after immediate postoperative period and rapid clinical response to targeted therapy. Another two cases of triple negative BC showed thyroid and lung metastasis in addition to skin metastasis, and their response of cytotoxic chemotherapy was not definite. The other hormone positive BC showed skin metastasis only, with a longer, slower, less progressive pattern than other subtypes. Most cases of skin metastasis were detected at terminal stage of malignancy and were considered to have a limited survival period. However, some BC patients can survive longer if the targeted agents are effective. Therefore, physicians should provide detailed follow up of BC after curative treatment and understand the metastatic pattern of BC according to the subtype.Keywords
This publication has 12 references indexed in Scilit:
- Patterns of Skin and Soft Tissue Metastases from Breast Cancer according to Subtypes: Relationship between EGFR Overexpression and Skin ManifestationsOncology, 2011
- “Targeting” Triple-Negative Breast Cancer: The Lessons Learned From BRCA1-Associated Breast CancersSeminars in Oncology, 2011
- Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platformsBMC Genomics, 2006
- Breast Cancer Molecular Subtypes Respond Differently to Preoperative ChemotherapyClinical Cancer Research, 2005
- Breast cancer classification and prognosis based on gene expression profiles from a population-based studyProceedings of the National Academy of Sciences, 2003
- Repeated observation of breast tumor subtypes in independent gene expression data setsProceedings of the National Academy of Sciences, 2003
- Skin Manifestations of Internal MalignancyClinics in Geriatric Medicine, 2002
- Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProceedings of the National Academy of Sciences, 2001
- Molecular portraits of human breast tumoursNature, 2000
- Cutaneous metastases in patients with metastatic carcinoma: A retrospective study of 4020 patientsJournal of the American Academy of Dermatology, 1993