Evaluation of the Effect of Extracerebral Layers in Cerebral Photoplethysmography (PPG) Using a Head Phantom

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Abstract
Optical brain monitoring techniques such as near-infrared spectroscopy (NIRS) and cerebral photoplethysmography (PPG) are promising non-invasive approaches for cerebral haemodynamic assessment; however, the measured signal can reflect contributions from both cerebral and extracerebral circulation. This study investigated the effect of extracerebral layers on forehead PPG signals using a multilayer head phantom with independent control of scalp and cerebral perfusion. Three perfusion conditions were performed: both layers perfused, scalp occlusion, and brain occlusion. PPG signals were acquired at 770, 810, and 880 nm using a custom optical probe with proximal (10 mm) and distal (30 mm) source–detector separations. Signal features were extracted and compared across conditions. Scalp occlusion produced a strong reduction in pulsatile signal, with complete signal collapse at the proximal detector. A small pulsatile signal (~5% of baseline amplitude) was detected at the distal detector, indicating that longer source–detector separations (30 mm) can detect signals originating from the brain phantom. Brain occlusion resulted in a partial amplitude reduction (~45%) with preserved waveform morphology across all wavelengths. While this demonstrates that cerebral perfusion changes are detectable in the presence of intact extracerebral circulation, it also highlights a potential masking effect as scalp circulation alone can produce a good-quality PPG signal despite complete cerebral hypoperfusion. These findings have clinical implications and highlight the need for mitigation strategies that account for extracerebral contributions in brain optical monitoring techniques.

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