Failure of rituximab in human immunodeficiency virus-associated multicentric Castleman disease

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Abstract
Two human immunodeficiency virus‐infected patients who needed etoposide therapy to control exacerbations of Castleman disease received four infusions of rituximab. Clinical and virologic relapses with increased blood human herpesvirus‐8 DNA levels occurred in both patients 4 and 24 weeks later and were associated with a worsening of Kaposi sarcoma. Am. J. Hematol. 79:337–339, 2005.