Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic Acid
Open Access
- 15 November 2024
- conference paper
- Published by MDPI AG in Chemistry Proceedings
- Vol. 16 (1) , 100
Abstract
In this work we present, a kinetic study of the Knoevenagel condensation reaction between 5-methoxy-1-tetralone and glyoxylic acid, catalyzed by sulfuric acid, to produce (E)-2-(5-methoxy-1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)acetic acid. The reaction was carried out in a batch system at 400 rpm for 24 h at temperatures of 75, 80 and 85 °C. The yields obtained at these temperatures were 90.30, 93.75 and 94.16%, respectively. The reaction was monitored by TLC and HPLC. For the kinetic analysis, three mathematical methods were used: integral, differential and non-linear regression. The results showed an excellent fit of the experimental data to the pseudo-first-order kinetic model.Keywords
Funding Information
- Universidad Central del Ecuador (DI-CONV-2022-049)
This publication has 10 references indexed in Scilit:
- Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeletonEuropean Journal of Medicinal Chemistry, 2022
- Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1ACS Medicinal Chemistry Letters, 2018
- A comparative review of escitalopram, paroxetine, and sertralineInternational Clinical Psychopharmacology, 2014
- Synthesis and aldose reductase inhibitory activity of a new series of benzo[h]cinnolinone derivativesIl Farmaco, 2000
- N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: Synthesis and Adrenergic and Dopaminergic Activity StudiesJournal of Medicinal Chemistry, 1998
- Macrocyclic Inhibitors of Penicillopepsin. 1. Design, Synthesis, and Evaluation of an Inhibitor Bridged between P1 and P3Journal of the American Chemical Society, 1998
- Iodinated 2-Aminotetralins and 3-Amino-1-benzopyrans: Ligands for Dopamine D2 and D3 ReceptorsJournal of Medicinal Chemistry, 1994
- Synthesis of (.+-.)-2'-trans-7-hydroxy-2-[N-(3'-iodo-2'-propenyl)-N-n-propylamino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligandJournal of Medicinal Chemistry, 1993
- Synthesis of 4-demethoxyanthracyclines carrying a lipophilic alkanoyl group at the C9-position.Chemical and Pharmaceutical Bulletin, 1986
- N-Aralkyl substitution of 2-amino-5,6- and -6,7-dihydroxy-1,2,3,4-tetrahydronaphthalenes. 2. Derivatives of a hypotensive-positive inotropic agentJournal of Medicinal Chemistry, 1982