Neural Signaling Metabolites May Modulate Energy Use in Hibernation
- 23 November 2016
- journal article
- review article
- Published by Springer Nature in Neurochemical Research
- Vol. 42 (1) , 141-150
Abstract
Despite an epidemic in obesity and metabolic syndrome limited means exist to effect adiposity or metabolic rate other than life style changes. Here we review evidence that neural signaling metabolites may modulate thermoregulatory pathways and offer novel means to fine tune energy use. We extend prior reviews on mechanisms that regulate thermogenesis and energy use in hibernation by focusing primarily on the neural signaling metabolites adenosine, AMP and glutamate.Keywords
Funding Information
- National Institute of Neurological Disorders and Stroke (NS081637)
- Directorate for Biological Sciences (IOS-1258179)
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