Refeeding of fasting rats stimulates DNA synthesis in implanted colon carcinoma

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Abstract
Colon carcinoma was implanted into the mesenterium of syngenic BD IX rats, and 10 weeks later the animals were fasted for 48 h and refed. Control animals were kept fasted for an additional 24-h period. DNA synthesis was measured in mucosal scrapings from the normal colon and in the tumor before and after refeeding. Autoradiography was used to determine the epithelial DNA synthesis index (labeling index) in the progenitor cells from normal colon imucosa, in the adenocarcinoma cells from the tumor, and in the tumor lymphocytes. DNA synthesis increased over control values in the normal mucosa in situ (Pppp<0.01) at 16 h after refeeding. No increase in labeling index was observed in the tumor lymphocytes. These data sugest that cell proliferation in normal colon epithelium as well as in colon adenocarcinoma cells may be stimulated by a common physiological factor released after feeding.

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