Ocular effects of two different prostaglandin F2α esters

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Abstract
Ocular hypotensive effects and side effects of two different topically applied prostaglandin (PG) esters were evaluated in a double masked study in 12 healthy males. Three doses of 15‐propionat‐PGF2α‐isopropylester (15‐prop‐PGF2α‐IE), two doses of PGF2α‐isopropylester (PGF2α‐IE), and placebo were compared. At equipotent doses 15‐prop‐PGF2α‐IE caused similar ocular side effects as PGF2α‐IE. It is concluded that both PGF2α‐IE and 15‐prop‐PGF2α‐IE reduce the IOP in normal eyes, but the use of a diester such as 15‐prop‐PGF2α‐IE does not provide a better separation between effect on IOP and side effects than PGF2α‐IE.