Highly scalable, wearable surface-enhanced Raman spectroscopy

Authors:
  • LLLimei Liu
    Limei Liu
  • PPPablo Martinez Pancorbo
    Pablo Martinez Pancorbo
  • TXTing-Hui Xiao
    Ting-Hui Xiao
  • SNSaya Noguchi
    Saya Noguchi
  • MMMachiko Marumi
    Machiko Marumi
  • SKSiddhant Karhadkar
    Siddhant Karhadkar
  • KHKotaro Hiramatsu
    Kotaro Hiramatsu
  • HSHiroki Segawa
    Hiroki Segawa
  • TITamitake Itoh
    Tamitake Itoh
  • JQJunle Qu
    Junle Qu
  • KTKuniharu Takei
    Kuniharu Takei
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Abstract
The last two decades have witnessed a dramatic growth of wearable sensor technology, mainly represented by flexible, stretchable, on-skin electronic sensors that provide rich information of the wearer's health conditions and surroundings. A recent breakthrough in the field is the development of wearable chemical sensors based on surface-enhanced Raman spectroscopy (SERS) that can detect molecular fingerprints universally, sensitively, and noninvasively. However, while their sensing properties are excellent, these sensors are not scalable for widespread use beyond small-scale human health monitoring due to their cumbersome fabrication process and limited multifunctional sensing capabilities. Here we demonstrate a highly scalable, wearable SERS sensor based on an easy-to-fabricate, low-cost, ultrathin, flexible, stretchable, adhesive, and bio-integratable gold nanomesh. It can be fabricated in any shape and worn on virtually any surface for label-free, large-scale, in-situ sensing of diverse analytes from low to high concentrations (10 nM - 1 mM). To show the practical utility of the wearable SERS sensor, we test the sensor for the detection of sweat biomarkers, drugs of abuse, and microplastics. This wearable SERS sensor represents a significant step toward the generalizability and practicality of wearable sensing technology.
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