Proton Pump Inhibitors Increase the Susceptibility of Mice to Oral Infection with Enteropathogenic Bacteria
- 11 January 2018
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 63 (4) , 881-889
Abstract
Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. Side effects including an increased risk of intestinal infections have been reported. It is assumed that PPIs can increase susceptibility to enteropathogens; however, the underlying mechanisms are unknown. Here in this study, we explored whether Lansoprazole (Laz), one of the PPIs, increases the susceptibility to enteropathogens, and further investigated the mechanism of it.Keywords
Funding Information
- Yakult Bio-Science Foundation
- Hyogo Science and Technology Association
- JST PRESTO (JPMJPR1537)
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