Effects of Total Sleep Deprivation in Major Depression: Overnight Improvement of Mood is Accompanied by Increased Pain Sensitivity and Augmented Pain Complaints

Authors:
  • JHJulia Hemmeter-Spernal
    Julia Hemmeter-Spernal
  • MHMartin Tobias Huber
    Martin Tobias Huber
  • JKJürgen-Christian Krieg
    Jürgen-Christian Krieg
  • SLStefan Lautenbacher
    Stefan Lautenbacher

Abstract
Objective: Major depressive disorder (MDD) is associated with more pain complaints and an altered pain perception. Studies regarding the longitudinal relationship between depressive symptoms and pain processing have rarely been performed and have produced inconsistent results. To clarify how short-term alleviation of depressive mood is linked to changes in pain processing, the effect of sleep deprivation (SD) on pain and somatosensory thresholds, pain complaints, and mood was investigated in MDD patients.

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