Site of Respiratory Reaction in Allergic Rats Challenged via the Airways

Authors:
  • FCF. Carswell
    F. Carswell
  • JOJean Oliver
    Jean Oliver
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Abstract
Rats systemically sensitized to DNP-ovalbumin show a characteristic respiratory response to antigen challenge delivered via the airway. The slowing of expiratory air flow which occurs on aerosol challenge still occurs when the antigen is injected via a tracheostomy but not when it is delivered solely to the upper airways. Disodium cromoglycate administered via the tracheostomy 1 min before intratracheal antigen challenge reduces the respiratory response.