Specificity of the antibody response of rabbits to a self-antigen

Authors:
  • RJRonald Jemmerson
    Ronald Jemmerson
  • EMEmanuel Margoliash
    Emanuel Margoliash

Abstract
The demonstration that the antigenic determinants on rabbit cytochrome c that elicit antibodies in rabbits occur in regions of variability among mammalian cytochromes c suggests the existence of an evolutionary process which eliminates genetic specificities for self-determinants.

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