The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile – development of a general synthetic strategy
- 30 June 2015
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 51 (62) , 12427-12430
Abstract
An Npys-mediated elimination method allows facile construction of the trademark functionality of the rakicidins – a new class of biologically-relevant Michael-acceptors.Keywords
Funding Information
- Kræftens Bekæmpelse (R40-A1775-B1086)
- Lundbeck Foundation (R105-A9308)
This publication has 23 references indexed in Scilit:
- Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of VinylamycinOrganic Letters, 2012
- A concise route to the macrocyclic core of the rakicidinsChemical Communications, 2011
- The resurgence of covalent drugsNature Reviews Drug Discovery, 2011
- Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr‐Abl positive leukemic cellsCancer Science, 2010
- Elucidating mechanisms of drug-induced toxicityNature Reviews Drug Discovery, 2005
- Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plantsFEBS Letters, 1990
- ACTIVATION OF CONVENTIONAL S-PROTECTING GROUPS OF CYSTEINE BY CONVERSION INTO THE 3-NITRO-2-PYRIDINESULFENYL (NPYS) GROUPChemistry Letters, 1982
- 3-NITRO-2-PYRIDINESULFENYL GROUP FOR PROTECTION AND ACTIVATION OF THE THIOL FUNCTION OF CYSTEINEChemistry Letters, 1981
- 3‐NITRO‐2‐PYRIDINESULFENYL (Npys) GROUPInternational Journal of Peptide and Protein Research, 1980
- A STABLE PYRIDINESULFENYL HALIDEChemistry Letters, 1978