PPARγ activators down‐regulate the expression of PPARγ in 3T3‐L1 adipocytes
- 26 March 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 447 (2-3) , 186-190
Abstract
Transcriptional activation of PPARγ by the anti‐diabetic compound troglitazone enhances the rate of 3T3‐L1 adipocyte differentiation. In this study, we examined the effects of troglitazone, a specific PPARγ ligand, on the expression of PPARγ during and after 3T3‐L1 adipocyte differentiation. Troglitazone treatment caused a significant decrease in PPARγ proteins and DNA binding activity. This reduction was associated with a similar decrease in transcription of PPARγ mRNA. These data suggest that in 3T3‐L1 cells, the expression of PPARγ is auto‐regulated.Keywords
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