Improving the solubility and bioavailability of anti-hepatitis B drug PEC via PEC–fumaric acid cocrystal
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Open Access
- 2 October 2020
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 10 (59) , 36125-36134
Abstract
A cocrystal of PEC with fumaric acid (FUA) (PEC–FUA, 1 : 1) was successfully obtained and characterized. The mean AUC 0–24 h of the cocrystal is about 4.2 times that of free PEC.Keywords
Funding Information
- National Natural Science Foundation of China (21567004)
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