The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances

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Abstract
There are complex interactions between the gut and the brain. With increasing research on the relationship between gut microbiota and brain function, accumulated clinical and preclinical evidence suggests that gut microbiota is intimately involved in the pathogenesis of neurodegenerative diseases (NDs). Increasingly studies are beginning to focus on the association between gut microbiota and central nervous system (CNS) degenerative pathologies to find potential therapies for these refractory diseases. In this review, we summarize the changes in the gut microbiota in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis and contribute to our understanding of the function of the gut microbiota in NDs and its possible involvement in the pathogenesis. We subsequently discuss therapeutic approaches targeting gut microbial abnormalities in these diseases, including antibiotics, diet, probiotics, and fecal microbiota transplantation (FMT). Furthermore, we summarize some completed and ongoing clinical trials of interventions with gut microbes for NDs, which may provide new ideas for studying NDs.
Funding Information
  • National Natural Science Foundation of China (No. 81973626, No. 81774059, No. 81973626, No. 81774059, No. 81973626, No. 81774059, No. 81973626, No. 81774059, No. 81973626, No. 81774059, No. 81973626, No. 81774059)
  • Tianjin Municipal Science and Technology Commission of China (No. 21JCYBJC01620, No. 21JCYBJC01620, No. 21JCYBJC01620)
  • Tianjin Health Committee (No. 2021099, No. 2021099, No. 2021099)
  • Tianjin Education Committee (No. 2021KJ146, No. 2021KJ146, No. 2021KJ146)

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