Strategies in the Discovery of Novel Antifungal Scaffolds
Authors:
- 27 July 2016
- journal article
- review article
- Published by Taylor & Francis in Future Medicinal Chemistry
- Vol. 8 (12) , 1435-1454
Abstract
The development of next-generation antifungal agents with novel chemical scaffolds and new mechanisms of action is vital due to increased incidence and mortality of invasive fungal infections and severe drug resistance. This review will summarize current strategies to discover novel antifungal scaffolds. In particular, high-throughput screening, drug repurposing, antifungal natural products and new antifungal targets are focused on. New scaffolds with validated antifungal activity, their discovery and optimization process as well as structure–activity relationships are discussed in detail. Perspectives that could inspire future antifungal drug discovery are provided.Keywords
Funding Information
- National Natural Science Foundation of China (81573283, 21502224)
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