Microbiological conversion of 19‐nortestosterone: (II) 10‐ and 11‐hydroxylation

Authors:
  • JFJ. de Flines
    J. de Flines
  • WWW. F. van der Waard
    W. F. van der Waard

Abstract
Fermentation of 19‐nortestosterone with Curvularia lunata or with Botrytis paeoniae yielded mainly the 10β‐hydroxy‐derivative. Fermentation with Aspergillus ochraceus afforded the 11α‐hydroxy‐derivative in good yield.10β‐Hydroxy‐19‐nortestosterone with Corynebacterium simplex yielded 10β, 17β‐dihydroxy‐19‐norandrosta‐1,4‐dien‐3‐one.

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