Effectiveness and Ethics of Incentives for Research Participation

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Abstract
Difficulty enrolling patients in randomized clinical trials (RCTs) is among the greatest barriers to evaluating health interventions.1-3 Because methods to improve RCT enrollment would greatly enhance the statistical power, generalizability, and efficiency of trials,1,4 there are increasing calls to embed evaluations of novel recruitment strategies within clinical trials.5-7 However, to our knowledge, interventions designed to improve RCT enrollment have largely failed.3,8-10

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