Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection
Open Access
- 7 February 2022
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Microbiology
- Vol. 13, 798660
Abstract
Graphical Retrovirus-induced MC degranulation promotes acute viral infection. The acute infection of MuLV/Friend virus triggers MC degranulation, which activates G-MDSCs to inhibit both CD8+ T- and NK cell-mediated antiviral immune responses; the HR1 antagonists Eastine and Loratadine that being used as the MC stabilizers block MC degranulation and consequently reverse degranulation-induced immune suppression for viral suppression. G-MDSCs, granulocyte-like myeloid derived suppressive cells; HR1, histamine receptor 1; iNOS, inducible nitric oxide synthase; MC, mast cell.Keywords
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