A New and Facile Method To Prepare Uniform Hollow MnO/Functionalized mSiO2 Core/Shell Nanocomposites

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Abstract
Trifunctional uniform nanoparticles comprising a manganese nanocrystal core and a functionalized mesoporous silica shell ([email protected]2(Ir)@PEG, where Ir is an emissive iridium complex and PEG is polyethylene glycol) have been strategically designed and synthesized. The T1 signal can be optimized by forming hollow core ([email protected]2(Ir)@PEG) via a novel and facile etching process, for which the mechanism has been discussed in detail. Systematic investigation on correlation for longitudinal relaxation (T1) versus core shapes and shell silica porosity of the nanocomposites (MnO, H-MnO, [email protected]2, [email protected]2, [email protected]2) has been carried out. The results show that the worm-like nanochannels in the mesoporous silica shell not only increase water permeability to the interior hollow manganese oxide core for T1 signal but also enhance photodynamic therapy (PDT) efficacy by enabling the free diffusion of oxygen. Notably, the [email protected]2(Ir)@PEG nanocomposite with promising r1 relaxivity demonstrates its versatility, in which the magnetic core provides the capability for magnetic resonance imaging, while the simultaneous red phosphorescence and singlet oxygen generation from the Ir complex are capable of providing optical imaging and inducing apoptosis, respectively.

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