Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
Open Access
- 22 April 2018
- journal article
- review article
- Published by MDPI AG in Biomedicines
- Vol. 6 (2) , 47
Abstract
Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia.Keywords
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Funding Information
- Cancer Researck UK (C99667/A12918)
- Wellcome Trust (097945/C/11/Z, 206293/Z/17/Z)
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