Effects of glutathione, as the dextran conjugate, on acetaminophen-induced hepatotoxicity.
Authors:
- Yoshiharu KaneoYKYoshiharu Kaneo
- Yumie FujiharaYFYumie Fujihara
- Tetsuro TanakaTTTetsuro Tanaka
- Yoko KozawaYKYoko Kozawa
- Hideki MoriHMHideki Mori
- Sadao IguchiSISadao Iguchi
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Chemical and Pharmaceutical Bulletin
- Vol. 37 (1) , 218-220
Abstract
Glutathine was covalently attached to dextran (T-40) by the CNBr activation method. In mice given a lethal dose of acetaminophen, the 30-d survival rate increased progressively with coadministration of the conjugate, whereas little improvement was found when free glutathione was given. the dextran conjugate of glutathione maintained the serum transaminase activities at lower levels after acetaminophen administration, giving effective protection against acetaminophen hepatotoxicity.Keywords
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