Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissues in the near infrared

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Abstract
Tissue glucose levels affect the refractive index of the extracellular fluid. The difference in refractive index between the extracellular fluid and the cellular components plays a role in determining the reduced scattering coefficient (μS′) of tissue. Hence a physical correlation may exist between the reduced scattering coefficient and glucose concentration. We have designed and constructed a frequency-domain near-infrared tissue spectrometer capable of measuring the reduced scattering coefficient of tissue with enough precision to detect changes in glucose levels in the physiological and pathological range.

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