Immunosuppressive therapy. Guidelines for drug dosage. Depression of bone marrow granulocyte reserves in systemic lupus erythematosus

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Abstract
Marrow granulocyte reserves, when estimated by the granulocyte response to etiocholanolone (GRE), are smaller in patients with systemic lupus erythematosus (SLE) than in a comparable group of patients with chronic glomerulonephritis (CGN). Consequently, the dose of azathioprine tolerated by patients with SLE was only one‐half that tolerated by patients with CGN. Use of the GRE as a guide to therapy may permit individualization of dosage so that maximum tolerated doses of immunosuppressive drugs can be given to each patient.

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