Quantification of asenapine and three metabolites in human plasma using liquid chromatography–tandem mass spectrometry with automated solid‐phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects

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Abstract
The development and validation of methods for determining concentrations of the antipsychotic drug asenapine (ASE) and three of its metabolites [N‐desmethylasenapine (DMA), asenapine‐N+‐glucuronide (ASG) and 11‐O‐sulfate‐asenapine (OSA)] in human plasma using LC‐MS/MS with automated solid‐phase extraction is described. The three assessment methods in human plasma were found to be acceptable for quantification in the ranges 0.0250–20.0 ng/mL (ASE), 0.0500–20.0 ng/mL (DMA and OSA) and 0.250–50.0 ng/mL (ASG). Copyright © 2011 John Wiley & Sons, Ltd.

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