Effects of simvastatin in abdominal sepsis in rats.
Open Access
- 1 January 2006
- journal article
- Published by FapUNIFESP (SciELO) in Acta Cirurgica Brasileira
- Vol. 21 (suppl 4) , 8-12
Abstract
Statins are widely recognized as hypolipemic drugs, but some studies have observed anti-inflammatory and immunomodulatory effects, known as pleiotropic. The aims of this work was to study possible anti-inflammatory effects of simvastatin in abdominal sepsis. Serum pro-inflammatory cytokines and leukocytes count were determined in an experimental model of abdominal sepsis, using cecal ligation and puncture (CLP) in rats.Keywords
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