Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent
Open Access
- 1 January 2007
- journal article
- research article
- Published by Springer Nature in Cardiovascular Diabetology
- Vol. 6 (1) , 15
Abstract
The atheroprotective effects of systemic delivery of either apolipoprotein A-I (wtApoA-I) or the naturally occurring mutant ApoA-I Milano (ApoA-IM) have been established in animal and human trials, but direct comparison studies evaluating the phenotype of ApoA-I or ApoAI-Milano knock-in mice or bone marrow transplantated animals with selectively ApoA-I or ApoAI-Milano transduced macrophages give conflicting results regarding the superior performance of either one. We therefore sought to compare the two forms of apoA-I using liver-directed somatic gene transfer in hypercholesterinemic mice – a model which is most adequately mimicking the clinical setting.Keywords
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