Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis
Authors:
Open Access
- 12 November 2015
- journal article
- Published by Spandidos Publications in Experimental and Therapeutic Medicine
- Vol. 11 (1) , 154-156
Abstract
Sepsis is a systemic inflammatory response of the body to an antigen and can become a life-threatening condition by triggering a cascade of changes leading to multiple organ failure such as heart failure. The aim of the present study was to examine the changes of the plasma levels of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in patients with sepsis and to analyze their prognostic significance. A total of 38 hospitalized patients with sepsis were included in the present study. The patients were divided into the survival and death groups, based on their prognosis. The plasma levels of NT-proBNP and cTnT for the two groups were measured for all the patients on the 1st, 3rd and 7th day of admission. The plasma levels of NT-proBNP and cTnT between the two groups were compared and their association with prognosis were analyzed. The plasma levels of NT-proBNP and cTnT in the death group were significantly higher than those in the survival group (P<0.05). Additionally, a positive assocciation of the plasma levels of NT-proBNP and cTnT was identified (P<0.05). In conclusion, the plasma levels of NT-proBNP and cTnT may be used as routine clinical biomarkers to assess the prognosis of patients with sepsis.Keywords
This publication has 24 references indexed in Scilit:
- Ciężka sepsa na oddziałach intensywnej terapii w Polsce — badanie chorobowości punktowej w latach 2012 i 2013Anaesthesiology Intensive Therapy, 2015
- Advances in Sepsis ResearchClinics in Chest Medicine, 2015
- Cardiovascular disease detection using bio-sensing techniquesTalanta, 2014
- 1:4 matched case-control study on influential factor of early onset neonatal sepsis.2013
- Procalcitonin as a diagnostic and prognostic marker for sepsis caused by intestinal infection: a case report.2013
- Influence of sepsis on higher daily dose of amikacin pharmacokinetics in critically ill patients.2013
- Serum N-terminal pro-brain natriuretic peptide level is a significant prognostic factor in patients with severe sepsis among Southwest Chinese population.2013
- Clinical Spectrum, Frequency, and Significance of Myocardial Dysfunction in Severe Sepsis and Septic ShockMayo Clinic Proceedings, 2012
- Management of Myocardial Dysfunction in Severe SepsisSeminars in Respiratory and Critical Care Medicine, 2011
- 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceIntensive Care Medicine, 2003