The genetic basis of the joint hypermobility syndromes
Authors:
- F. MalfaitF. Malfait
- A. J. HakimAHA. J. Hakim
- A. De PaepeAPA. De Paepe
- R. GrahameRGR. Grahame
Open Access
- 17 January 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 45 (5) , 502-507
Abstract
Rheumatologists have long considered that joint hypermobility is inherited. The familial aggregation is striking and the pattern of inheritance strongly points to an autosomal dominant mode. The first comprehensive description of symptomatic joint hypermobility in the rheumatological literature is attributed to Kirk, Ansell and Bywaters in 1967 [1]. They coined the term ‘hypermobility syndrome’ (HMS). Later, the recognition of the relatively benign prognosis of the HMS in terms of life-threatening complications led to the use of the term ‘benign joint hypermobility syndrome’ (BJHS) or latterly, the ‘joint hypermobility syndrome’ (JHS).Keywords
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