Rhodium-catalyzed one-pot tandem reductive amination/asymmetric transfer hydrogenation of quinoxaline-2-carbaldehydes and anilines for the efficient synthesis of chiral vicinal diamines
- 13 May 2025
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic Chemistry Frontiers
- Vol. 12 (18) , 5011-5017
Abstract
Chiral N,N′-diaryl vicinal diamines have been synthesized enantioselectively via Cp*Rh-catalyzed tandem reductive amination/asymmetric transfer hydrogenation of quinoxaline-2-carbaldehydes with anilines using HCO2H/NEt3 (5/2) as the hydrogen source.Keywords
Funding Information
- National Natural Science Foundation of China (21372258)
- Renmin University of China
This publication has 76 references indexed in Scilit:
- Asymmetric Transfer Hydrogenation of 3‐Substituted 2H‐1,4‐Benzoxazines under Tethered Cp*Rh(III)‐Diamine Catalysis with Unexpected Reversal of EnantioselectivityAdvanced Synthesis & Catalysis, 2024
- Iridium‐Catalyzed Asymmetric Transfer Hydrogenation for Facile Access to Optically Active Dihydrodibenzo‐Fused AzepinesAdvanced Synthesis & Catalysis, 2024
- Metal‐Free Reductive Amination of Ketones with Amines Using Formic Acid as the Reductant under BF3 ⋅ Et2O CatalysisAsian Journal of Organic Chemistry, 2022
- Nickel‐Catalyzed Enantioselective Reductive Amination of Ketones with Both Arylamines and BenzhydrazideAngewandte Chemie International Edition, 2016
- Iridium‐Catalyzed Transfer Hydrogenation of 1,10‐Phenanthrolines using Formic Acid as the Hydrogen SourceAdvanced Synthesis & Catalysis, 2016
- Asymmetric Ruthenium‐Catalyzed Hydrogenation of 2,6‐Disubstituted 1,5‐Naphthyridines: Access to Chiral 1,5‐Diaza‐cis‐DecalinsAngewandte Chemie International Edition, 2015
- pH‐Regulated Asymmetric Transfer Hydrogenation of Quinolines in WaterAngewandte Chemie International Edition, 2009
- The Fluorenone Imines of Glycine Esters and Their Phosphonic Acid AnaloguesAngewandte Chemie International Edition, 2008
- Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of KetonesAngewandte Chemie International Edition, 2001
- The Chemistry of Vicinal DiaminesAngewandte Chemie International Edition, 1998