Palladium/Tetraphosphine Catalysed Heck Reaction with ortho-Substituted Aryl Bromides

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Abstract
The tetraphosphine cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane associated to [PdCl(C3H5)]2 catalyses the Heck reaction of butyl acrylate with a wide range of sterically demanding aryl bromides, furnishing the addition product in high yields. Turnover numbers as high as 630-89 000 have been obtained using ortho-substituted aryl bromides and 43-2600 with di-ortho-substituted aryl bromides in the presence of this catalyst.